EGFR T790M/L858R-IN-2
Product Specifications
Target
Others, EGFR, Apoptosis
Related Pathways
JAK/STAT signaling, Others, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis
Bioactivity
EGFRT790M/L858R-IN-2 is a potent, selective inhibitor of EGFRT790M/L858R, exhibiting IC50 values of 3.5 nM for EGFRT790M/L858R and 1290 nM for EGFR WT. This compound effectively decreases the expression of p-EGFR, P-AKT, P-ERK1/2, and induces apoptosis as well as cell cycle arrest in the G1 phase, demonstrating anti-cancer activity [1].
Molecular Formula
C28H28FN7O
Molecular Weight
497.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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