PROTAC GPX4 degrader-1
Product Specifications
CAS Number
2916433-81-1
Target
Glutathione Peroxidase|||PROTACs|||Ferroptosis
Related Pathways
PROTAC|||Apoptosis|||Metabolism
Bioactivity
PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 ?M in HT1080 cells [1].
Smiles
O=C1C2=C(NCCCN3CCN(CC3)CC4CCN(CC4)C(COC5=CC=C(C=C5)C(C6=CC=C(C=C6)Cl)N7CCN(CC7)C(C8=NOC(C)=C8[N+]([O-])=O)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
Molecular Formula
C50H57ClN10O10
Molecular Weight
993.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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