USP28-IN-4
Product Specifications
CAS Number
2931509-15-6
Target
DUB
Related Pathways
Ubiquitination, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9848
Bioactivity
USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.
Smiles
O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C
Molecular Formula
C22H18Cl2N2O3S
Molecular Weight
461.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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