FtsZ-IN-8

FtsZ-IN-8, a potent inhibitor of FtsZ, both promotes FtsZ polymerization and inhibits its GTPase activity, leading to the inhibition of bacterial division and subsequent bacterial cell death. This compound exhibits bactericidal activity without significant induction of bacterial resistance and possesses rapid bactericidal properties. Additionally, FtsZ-IN-8 demonstrates low hemolytic activity and cytotoxicity towards mammalian cells [1].