FtsZ-IN-6

FtsZ-IN-6 is a potent inhibitor of FtsZ, enhancing its polymerization while inhibiting its GTPase activity, thereby obstructing bacterial cell division and causing bacterial cell death. This compound exhibits bactericidal properties without significant induction of bacterial resistance and demonstrates rapid bactericidal effects. Moreover, FtsZ-IN-6 has low hemolytic activity and cytotoxicity towards mammalian cells [1].