Gly-Cyclopropane-Exatecan
Product Specifications
CAS Number
2414254-49-0
Target
ADC Cytotoxin, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Antibody-drug Conjugate/ADC Related
Bioactivity
Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34) . This compound demonstrated antitumor activity both in vivo and in vitro [1].
Smiles
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](NC(=O)C(OCNC(=O)CN)C6CC6)c(c3Cn1c2=O)c45
Molecular Formula
C32H34FN5O7
Molecular Weight
619.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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