A947
Product Specifications
CAS Number
2378056-80-3
Target
PROTACs, Apoptosis, Epigenetic Reader Domain
Related Pathways
PROTAC, Chromatin/Epigenetic, Apoptosis
Purity
0.9884
Bioactivity
A947 is a potent and selective SMARCA2 protein hydrolysis-targeted chimeric molecule (PROTAC) that induces the degradation of SMARCA2 by binding to VHL E3 ubiquitin ligase, with significant antitumor activity in vivo and in vitro, especially in SMARCA4-mutant non-small cell lung cancer (NSCLC) cells.
Smiles
O(C1=CC(N2C3CN(CC2CC3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)=CC=N1)[C@H]6C[C@H](OC7CCN(CC8CCN(CC8)C=9C=C([C@H](C(=O)N%10[C@H](C(N[C@@H](C)C%11=CC=C(C=C%11)C=%12SC=NC%12C)=O)C[C@@H](O)C%10)C(C)C)ON9)CC7)C6
Molecular Formula
C61H76N12O7S
Molecular Weight
1121.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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