NecroIr1
Product Specifications
Target
Others, MLK, RIP kinase, CDK
Related Pathways
Others, NF-κB, MAPK, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
NecroIr1, an iridium (III) complex, acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R) . It selectively targets mitochondria, causing oxidative stress and reducing mitochondrial membrane potential (MMP) . By activating receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and modulating CDK4 expression, NecroIr1 facilitates cell death mechanisms [1].
Molecular Formula
C40H29ClIrN5O-
Molecular Weight
823.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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