Setidegrasib
Product Specifications
CAS Number
2821793-99-9
Target
PROTACs, Ras, Others, Kras
Related Pathways
GPCR/G Protein, Others, PROTAC, MAPK
Bioactivity
Setidegrasib (example 8), a quinazoline-linked (4R) -4-hydroxy-L-prolinamide compound, acts as a proteolysis targeting chimera (PROTAC) [1], specifically inducing degradation of the G12D-mutation KRAS protein.
Smiles
[H][C@]12CN(c3nc(OC4CCOCC4)nc4c(OCc5ccc(cc5)-c5cn(nn5)[C@@H](C(C)C)C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](CO)c5ccc(cc5)-c5scnc5C)c(c(cc34)C3CC3)-c3c(C)c(F)cc4[nH]ncc34)[C@]([H])(CN1)C2
Molecular Formula
C60H65FN12O7S
Molecular Weight
1117.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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