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RNA polymerase II-IN-1

Product Specifications

CAS Number

2891451-07-1

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Bioactivity

RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM and exhibits heightened cytotoxicity towards cancer cells while reducing toxicity in normal cells compared to ?-Amanitin [1].

Molecular Formula

C38H53N11O12S

Molecular Weight

887.96

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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