PROTAC EZH2 Degrader-1
Product Specifications
CAS Number
2641601-67-2
Target
PROTACs, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC molecule that effectively suppresses EZH2 methyltransferase activity, with a half-maximal IC50 of 2.7 nM. EZH2 is a histone methyltransferase crucial to tumorigenesis and cancer progression, and PROTAC EZH2 Degrader-1 represents an important chemical tool for probing its therapeutic relevance.
Smiles
O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC(=C2C)N(CC)C3CCOCC3)C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
Molecular Formula
C54H67N7O8
Molecular Weight
942.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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