PROTAC EZH2 Degrader-1
Product Specifications
CAS Number
2641601-67-2
Target
PROTACs, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC molecule that effectively suppresses EZH2 methyltransferase activity, with a half-maximal IC50 of 2.7 nM. EZH2 is a histone methyltransferase crucial to tumorigenesis and cancer progression, and PROTAC EZH2 Degrader-1 represents an important chemical tool for probing its therapeutic relevance.
Smiles
O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC(=C2C)N(CC)C3CCOCC3)C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
Molecular Formula
C54H67N7O8
Molecular Weight
942.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
M-CEM-Q2100CR21.2 100 Grids
Quantifoil R 1.2/20; Copper 200 Mesh 100/pk
Sign In for Pricing
View Details 
bs-1183R-BF680-TR 20 µL
IL17A Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Sign In for Pricing
View Details 032509-FITC 200 µL
BHLHB5, ID (BHLHE22, BHLHB5, TNRC20, Class E basic helix-loop-helix protein 22, Class B basic helix-loop-helix protein 5, Trinucleotide repeat-containing gene 20 protein) (FITC) discontinued
Sign In for Pricing
View Details