Keap1-Nrf2-IN-9
Product Specifications
CAS Number
2769963-24-6
Target
Others, Nrf2
Related Pathways
Immunology/Inflammation, Others
Bioactivity
Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with an IC50 value of 0.575 μM, enhancing the expression of Nrf2 target genes such as heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits, while not being cytotoxic to ARPE19 cells [1].
Smiles
COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)c1ccc(N(CC(O)=O)S(=O)(=O)c2ccc(OC)cc2)c(OCc2ccccc2)c1
Molecular Formula
C31H30N2O11S2
Molecular Weight
670.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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