SJ1008030
Product Specifications
CAS Number
2863634-96-0
Target
Others, JAK, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC, JAK/STAT signaling, Stem Cells, Others, Chromatin/Epigenetic
Bioactivity
SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].
Smiles
CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NCCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)nc2[nH]ccc12
Molecular Formula
C42H43N13O7S
Molecular Weight
873.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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