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Rofapitide tetraxetan

Product Specifications

CAS Number

2581741-18-4

Target

Immunology/Inflammation related, Others

Related Pathways

Immunology/Inflammation, Others

Purity

0.9546

Bioactivity

Rofapitide tetraxetan (FAP-2286) is a high-affinity, selective inhibitor of fibroblast activating protein (FAP) and a DOTA-pseudopeptide with an IC50 of 1.3–2.2 nM. FAP-2286 targets the tumour microenvironment and can be radiolabelled (e.g., with 68Ga) for use in positron emission tomography (PET) imaging.

Smiles

[H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CSCc1cc(CSCCNC(=O)CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3)cc(CSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@]([H])(NC2=O)[C@@H](C)O)C(O)=O)c1)NC(=O)CCCCC

Molecular Formula

C67H99N13O18S3

Molecular Weight

1470.77

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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