PROTAC EGFR degrader 6
Product Specifications
CAS Number
2409793-28-6
Target
Others, PROTACs, Apoptosis, EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, Others, PROTAC, JAK/STAT signaling
Bioactivity
PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].
Smiles
OCC1CCN(CC1)c1nc(Nc2ccc(F)cc2)nc2cnc(Nc3ccc(cn3)N3CCN(CCCCCCCC(=O)Nc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)CC3)cc12
Molecular Formula
C49H57FN12O5
Molecular Weight
913.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSM040815-01 100 µg
Recombinant Mouse ICOS Ligand/ICOSL Protein (His Tag)
Sign In for Pricing
View Details PKSM040815-02 1 mg
Recombinant Mouse ICOS Ligand/ICOSL Protein (His Tag)
Sign In for Pricing
View Details 
![NCOA7 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2E12]](https://cdn.genprice.uk/products/937/6868c409994c49e6dc4047dc/imageurl/ta810476am.webp)
TA810476AM 100 µL
NCOA7 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2E12]
Sign In for Pricing
View Details