PROTAC EGFR degrader 6
Product Specifications
CAS Number
2409793-28-6
Target
Others, PROTACs, Apoptosis, EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis, Others, PROTAC, JAK/STAT signaling
Bioactivity
PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells [1].
Smiles
OCC1CCN(CC1)c1nc(Nc2ccc(F)cc2)nc2cnc(Nc3ccc(cn3)N3CCN(CCCCCCCC(=O)Nc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)CC3)cc12
Molecular Formula
C49H57FN12O5
Molecular Weight
913.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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