SS47
Product Specifications
CAS Number
2636072-62-1
Target
Others, PROTACs, MAPK
Related Pathways
Others, PROTAC, MAPK
Bioactivity
SS47, a PROTAC-based HPK1 degrader, induces proteasome-mediated HPK1 degradation and significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies [1].
Smiles
O=C1C=2C=CC=C(OCCOCCOCCOCCOCCC(=O)N3CCC(C4=NC=C(S4)C=5C=NC(N)=C(OCC=6C=CC=C(C#CC(O)(C)C)C6)C5)CC3)C2C(=O)N1C7C(=O)NC(=O)CC7
Molecular Formula
C49H56N6O12S
Molecular Weight
953.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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