NHEJ inhibitor-1
Product Specifications
Target
Others, Reactive Oxygen Species
Related Pathways
Metabolism, Immunology/Inflammation, NF-κB, Others
Bioactivity
NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt (II) complex, mitigates non-homologous end joining (NHEJ) /homologous recombination (HR) -related double strand break (DSB) repairs, combating Cisplatin resistance in non-small cell lung cancer (NSCLC) . It achieves this by inhibiting the damage repair proteins Ku70 and Rad51, thus re-sensitizing tumors to Cisplatin. Additionally, this compound prompts the generation of reactive oxygen species (ROS) and reduces mitochondrial membrane potential (MMP) [1].
Molecular Formula
C30H35N7O8PtS
Molecular Weight
848.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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