JPS036
Product Specifications
CAS Number
2669785-85-5
Target
PROTACs, Others, HDAC
Related Pathways
Others, PROTAC, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
JPS036, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), efficiently degrades class I histone deacetylase (HDAC), particularly HDAC1/2. Its activity results in a substantial increase in differentially expressed genes and promotes enhanced apoptosis in HCT116 cells [1].
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCCCCCCCCCCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)c1
Molecular Formula
C51H66FN7O7S
Molecular Weight
940.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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