JPS016
Product Specifications
CAS Number
2669785-77-5
Target
PROTACs, Others, HDAC
Related Pathways
Others, Chromatin/Epigenetic, DNA Damage/DNA Repair, PROTAC
Bioactivity
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC) . It serves as a potent HDAC1/2 degrader, resulting in a significant increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1
Molecular Formula
C48H63N7O8S
Molecular Weight
898.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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