JPS014

Product Specifications

CAS Number

2669785-76-4

Target

PROTACs|||Others|||HDAC

Related Pathways

Others|||DNA Damage/DNA Repair|||PROTAC|||Chromatin/Epigenetic

Bioactivity

JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1

Molecular Formula

C46H59N7O7S

Molecular Weight

854.07

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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