β-Glucuronide-dPBD-PEG5-NH2

Product Specifications

CAS Number

2246363-68-6

Target

Apoptosis|||Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related|||Apoptosis

Bioactivity

?-Glucuronide-dPBD-PEG5-NH2 is a ?-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, utilizing a cleavable ?-glucuronide linkage. This compound targets and binds to the prenylated antibody, facilitating controlled drug release to mitigate side effects and exhibits antitumor properties by inducing apoptosis and arresting the cell cycle [1].

Smiles

[H][C@@]12CC(=C)CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N(C(O)[C@]5([H])CC(=C)CN5C(=O)c4cc3OC)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(c3)C(=O)NCCOCCOCCOCCOCCOCCON)cc1N(C2O)C(=O)OCc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)c(c1)C(=O)NCCOC