XY-06-007
Product Specifications
CAS Number
2757045-94-4
Target
PROTACs, Epigenetic Reader Domain, Others
Related Pathways
Others, PROTAC, Chromatin/Epigenetic
Bioactivity
XY-06-007, a potent and selective bump-and-hole (B&H) PROTAC BRD4 BD1 L94V degrader, exhibits a DC50, 6 h of 10 nM specifically against BRD4 BD1 L94V without degrading off-targets. It also demonstrates favorable pharmacokinetics for in vivo studies [1].
Smiles
[H][C@]1(N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12)[C@@H](C)C(=O)NCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Molecular Formula
C41H41ClN8O8
Molecular Weight
809.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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