LEB-03-146
Product Specifications
CAS Number
2858812-91-4
Target
Wee1|||Others
Related Pathways
Others|||Cell Cycle/Checkpoint
Bioactivity
LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B hepatoma cancer cells [1].
Smiles
CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCOCCOCCNC(=O)CCc4ccc(o4)N4CCN(CC4=O)C(=O)C=C)CC3)nc12
Molecular Formula
C46H57N11O8
Molecular Weight
892.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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