MEK/PI3K-IN-2
Product Specifications
CAS Number
2281803-33-4
Target
MEK, Others, PERK, PI3K
Related Pathways
Others, PI3K/Akt/mTOR signaling, Apoptosis, MAPK
Bioactivity
MEK/PI3K-IN-2 (compound 6s), a potent inhibitor of both MEK and PI3K, demonstrates IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), effectively reducing pAKT and pERK1/2 levels and exhibiting anti-proliferative activity against various tumor cell lines [1].
Smiles
OCCN(CCOCCOCCOCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)c1nc(nc(n1)-n1c(nc2ccccc12)C(F)F)N1CCOCC1
Molecular Formula
C38H41F5IN9O7
Molecular Weight
957.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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