PP-C8
Product Specifications
Target
PROTACs, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint
Bioactivity
PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1].
Molecular Formula
C43H51FN12O7
Molecular Weight
866.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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