YF135
Product Specifications
CAS Number
2913177-53-2
Target
Ras|||PROTACs|||Others|||Kras|||PERK
Related Pathways
MAPK|||PROTAC|||Others|||Apoptosis
Bioactivity
YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhibitor 48 (compound 6d) as the ligand, YF135 utilizes the MRTX849 linkage VHL ligand scaffold.
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
Molecular Formula
C63H75ClN12O7S
Molecular Weight
1179.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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