PSI-353661
Product Specifications
CAS Number
1231747-08-2
Target
Others, HCV Protease
Related Pathways
Others, Microbiology/Virology, Proteases/Proteasome
Bioactivity
PSI-353661 (GS-558093), a purine nucleotide NS5B polymerase inhibitor, is effective against HCV infection, displaying EC90 values of 8 nM and 11 nM for wild-type and S282T resistant HCV replicons, respectively. It is capable of generating high concentrations of the active triphosphate form in primary human hepatocytes [1] [3].
Smiles
COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc2ccccc2)[C@@H](O)[C@@]1(C)F
Molecular Formula
C24H32FN6O8P
Molecular Weight
582.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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