Bcl-2-IN-4
Product Specifications
CAS Number
2703134-40-9
Target
Bcl-2 Family, Others
Related Pathways
Others, Apoptosis
Bioactivity
Bcl-2-IN-4, an orally active and selective inhibitor of Bcl-2, demonstrates potent efficacy with an IC50 value of 1.5 nM and exhibits more than 200-fold selectivity over Bcl-xL (IC50 of 411 nM) . Additionally, it effectively inhibits the proliferation of RS4;11 cells, achieving an IC50 of 2.7 nM.
Smiles
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cc(c(NCC4CCOCC4)c4nc[nH]c34)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1
Molecular Formula
C46H50ClN9O7S
Molecular Weight
908.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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