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FAK PROTAC B5

Product Specifications

CAS Number

2471525-44-5

Target

PROTACs, FAK, Others

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, Others, PROTAC, Cytoskeletal Signaling

Bioactivity

Compound B5 (FAK PROTAC B5) is a FAK PROTAC degrader exhibiting potent FAK degradation and antiproliferative activities, with an IC50 of 14.9 nM. It also shows excellent plasma stability, moderate membrane permeability, and inhibits cell migration and invasion [1].

Smiles

CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(CCCCC(=O)Nc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)ncc1Cl

Molecular Formula

C41H43ClN10O7

Molecular Weight

823.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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