FAK PROTAC B5
Product Specifications
CAS Number
2471525-44-5
Target
PROTACs|||FAK|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||Others|||PROTAC|||Cytoskeletal Signaling
Bioactivity
Compound B5 (FAK PROTAC B5) is a FAK PROTAC degrader exhibiting potent FAK degradation and antiproliferative activities, with an IC50 of 14.9 nM. It also shows excellent plasma stability, moderate membrane permeability, and inhibits cell migration and invasion [1].
Smiles
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(CCCCC(=O)Nc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)ncc1Cl
Molecular Formula
C41H43ClN10O7
Molecular Weight
823.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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