JB170
Product Specifications
CAS Number
2705844-82-0
Target
Aurora Kinase, PROTACs
Related Pathways
PROTAC, Chromatin/Epigenetic, Cell Cycle/Checkpoint
Purity
0.9982
Bioactivity
JB170 is a highly efficient and specific Aurora A degradator (DC50 = 28 nM) . The PROTAC is composed of Alisertib and Thalidomide, with an EC50 value for AURORA-A that is ten times that of AURORA-B. It induces S-phase arrest in cell growth and inhibits the non-catalytic function of the AURORA-A kinase.
Smiles
O=C(NCCOCCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4OC)NC=5N=CC6=C(N5)C=7C=CC(Cl)=CC7C(=NC6)C=8C(F)=CC=CC8OC
Molecular Formula
C48H44ClFN8O11
Molecular Weight
963.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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