PROTAC BRD4 Degrader-12
Product Specifications
CAS Number
2417370-90-0
Target
Epigenetic Reader Domain, PROTAC-Linker Conjugates for PAC, PROTACs, Others
Related Pathways
PROTAC, Chromatin/Epigenetic, Antibody-drug Conjugate/ADC Related, Others
Bioactivity
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].
Smiles
CC(OC(=O)O[C@@H]1C[C@H](N(C1)C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c1cc2N(Cc3c[nH]c4c3c(cn(C)c4=O)-c2cc1CS(C)(=O)=O)c1ncc(F)cc1F)C(C)(C)C)C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)SS(C)(=O)=O
Molecular Formula
C62H77F2N9O12S4
Molecular Weight
1306.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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