Polyinosinic-polycytidylic acid potassium

Polyinosinic-polycytidylic acid potassium (Poly (I:C) potassium), a synthetic double-stranded RNA analog, serves as an agonist for toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I) -like receptors (RIG-I and MDA5), offering applications in immunotherapy. Its sodium variant enhances both innate and adaptive immune responses when used as a vaccine adjuvant and is instrumental in modifying the tumor microenvironment. Additionally, Poly (I:C) potassium can directly induce apoptosis in cancer cells [1] [2] [3].