What is the catalog number for ONX-0914 TFA?

The catalog number for ONX-0914 TFA is T73986.

What sizes are available for ONX-0914 TFA?

ONX-0914 TFA is available in the following size(s): 5 mg, 50 mg.

How many pack sizes does ONX-0914 TFA come in?

ONX-0914 TFA is available in 2 different pack sizes.

Is ONX-0914 TFA in stock?

ONX-0914 TFA is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ONX-0914 TFA?

ONX-0914 TFA is manufactured by Molfinity.

What is the estimated delivery time for ONX-0914 TFA?

Estimated delivery time for ONX-0914 TFA is approximately 10 business day(s), depending on your location.

ONX-0914 TFA

Product Specifications

Target

Others, Proteasome, HIV Protease, Antibacterial

Related Pathways

Ubiquitination, Microbiology/Virology, Others, Proteases/Proteasome

Bioactivity

ONX-0914 (PR-957) TFA is a selective, noncompetitive, irreversible inhibitor of the chymotrypsin-like subunit (LMP7) of the immunoproteasome, effectively blocking cytokine production and mitigating experimental arthritis progression. With a K_i value of 5.2 μM against the mycobacterial proteasome, ONX-0914 TFA also reactivates latent HIV-1 by inducing p-TEFb activation through HSF-1 mediation [1] [2] [3].