ONX-0914 TFA
Product Specifications
Target
Others|||Proteasome|||HIV Protease|||Antibacterial
Related Pathways
Ubiquitination|||Microbiology/Virology|||Others|||Proteases/Proteasome
Bioactivity
ONX-0914 (PR-957) TFA is a selective, noncompetitive, irreversible inhibitor of the chymotrypsin-like subunit (LMP7) of the immunoproteasome, effectively blocking cytokine production and mitigating experimental arthritis progression. With a K_i value of 5.2 ?M against the mycobacterial proteasome, ONX-0914 TFA also reactivates latent HIV-1 by inducing p-TEFb activation through HSF-1 mediation [1] [2] [3].
Molecular Formula
C33H41F3N4O9
Molecular Weight
694.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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