MsbA-IN-6

MsbA-IN-6 is a potent antibiotic and inhibitor of the gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential protein for transporting lipopolysaccharide across the inner bacterial membrane. It exerts a bactericidal effect on Escherichia coli by inhibiting the ATPase and transport activity of MsbA, while retaining efficacy against multidrug-resistant clinical strains [1] [2].