Paritaprevir dihydrate
Product Specifications
CAS Number
1456607-71-8
Target
Others, SARS-CoV, HCV Protease
Related Pathways
Proteases/Proteasome, Others, Microbiology/Virology
Bioactivity
Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a and 1b, respectively. Additionally, it functions as a SARS-CoV 3CL pro inhibitor with an IC50 of 1.31 μM. Primarily metabolized by cytochrome P450 (CYP) 3A, its plasma concentration and half-life are significantly increased when administered with Ritonavir, a CYP450 inhibitor [1] [2] [3] [4].
Smiles
O.O.Cc1cnc(cn1)C(=O)N[C@H]1CCCCC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C1=O)Oc1nc2ccccc2c2ccccc12)C(=O)NS(=O)(=O)C1CC1
Molecular Formula
C40H47N7O9S
Molecular Weight
801.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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