Anticancer agent 39

Anticancer Agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), not only induces apoptosis through the collapse of mitochondrial membrane potential (MMP) but also inhibits cell cloning and migration, demonstrating promising anti-proliferative activity against HGC-27 cells with an IC50 value of 0.39 μM [1].

[H][C@@]12C[C@H](O)[C@]3([H])[C@@]([C@@H]1O)(C(=O)C2=C)[C@@]1([H])C[C@]2([H])C(C)(C)CCC[C@@]32[C@H](OCCCc2cn(CCOCCOCCOCCN3C(=O)c4cccc5c(ccc(C3=O)c45)N3CCCCC3)nn2)O1