GGTI-286 TFA
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
GGTI-286 TFA is a potent, cell-permeable inhibitor of GGTase I, exhibiting 25 times greater effectiveness (IC 50 = 2 ?M) compared to the corresponding methyl ester of FTI-276. It specifically targets the geranylgeranylation of Rap1A, demonstrating significant selectivity over the farnesylation of H-Ras in NIH3T3 cells (IC 50s = 2 and >30 ?M, respectively) . Additionally, GGTI-286 TFA effectively inhibits the stimulation of oncogenic K-Ras4B with an IC 50 of 1 ?M.
Molecular Formula
C25H32F3N3O5S
Molecular Weight
543.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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