Cis-Lomibuvir
Product Specifications
CAS Number
1026785-59-0
Target
DNA/RNA Synthesis, Others, HCV Protease
Related Pathways
Proteases/Proteasome, Others, DNA Damage/DNA Repair, Microbiology/Virology, Cell Cycle/Checkpoint
Bioactivity
Cis-Lomibuvir (cis-VX-222), a cis-isomer of Lomibuvir, is a selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase (RdRp), targeting thumb pocket 2 with a dissociation constant (Kd) of 17 nM. It exhibits an EC50 of 5.2 nM against the 1b/Con1 HCV subgenomic replicon, demonstrating a preference for inhibiting elongative RNA synthesis over de novo-initiated RNA synthesis.
Smiles
C[C@H]1CC[C@@H](CC1)C(=O)N([C@@H]1CC[C@@H](CC1)O)c1c(sc(c1)C#CC(C)(C)C)C(=O)O
Molecular Formula
C25H35NO4S
Molecular Weight
445.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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