Milademetan tosylate hydrate
Product Specifications
CAS Number
2095625-97-9
Target
Others, Apoptosis, E1/E2/E3 Enzyme, MDM-2/p53
Related Pathways
Others, Ubiquitination, Apoptosis
Bioactivity
Milademetan (DS-3032) tosylate hydrate, an orally active and specific MDM2 inhibitor, is utilized in the study of acute myeloid leukemia (AML) and solid tumors. It induces G1 cell cycle arrest, senescence, and apoptosis, showcasing its therapeutic potential [1] [2].
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.O=C1[C@@]2(C3(N[C@@H](C(N[C@@H]4CC[C@@H](C(N)=O)OC4)=O)[C@@H]2C=5C(F)=C(Cl)N=CC5)CCC(C)(C)CC3)C=6C(N1)=CC(Cl)=CC6.O
Molecular Formula
C37H44Cl2FN5O8S
Molecular Weight
808.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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