EP39
Product Specifications
Target
Others, HIV Protease
Related Pathways
Others, Proteases/Proteasome, Microbiology/Virology
Bioactivity
EP39, a potent HIV-1 maturation inhibitor, binds to the QVT motif within the SP1 domain of Gag, reducing the dynamics at the CA-SP1 junction and disrupting the coil-helix equilibrium adjacent to the SP1 domain by stabilizing the transient alpha-helical structure. This action arrests HIV-1 maturation, effectively blocking its infectivity.
Smiles
C=C(C)[C@@H]1CC[C@]2(C(=O)NCCN)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)C5CC[C@]43C)C12
Molecular Formula
C38H62N2O5
Molecular Weight
626.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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