I-138
Product Specifications
CAS Number
2098211-50-6
Target
DUB
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Ubiquitination
Purity
0.9941
Bioactivity
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
Smiles
C(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C
Molecular Formula
C26H23F3N6O
Molecular Weight
492.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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