Nec-3a
Product Specifications
CAS Number
1504558-72-8
Target
Others, RIP kinase
Related Pathways
Apoptosis, Others, NF-κB
Bioactivity
Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM. This compound successfully impedes the autophosphorylation activity within the RIP1 kinase domain.
Smiles
C(CO)(=O)N1[C@@H]([C@]2(C(=N1)C=3C(CC2)=CC=C(OC)C3)[H])C4=CC(F)=C(OC(F)(F)F)C=C4
Molecular Formula
C21H18F4N2O4
Molecular Weight
438.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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