GSK761
Product Specifications
Target
Others, Epigenetic Reader Domain
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
GSK761, a selective inhibitor of speckled 140 kDa (SP140), exhibits an IC50 value of 77.79 nM. It impedes the differentiation of monocytes into inflammatory macrophages and attenuates lipopolysaccharide (LPS) -induced inflammatory activation. Furthermore, GSK761 promotes the generation of CD206+ regulatory macrophages through the inhibition of SP140.
Smiles
CC(C)(C)OCCC1=CC(=CC=C1)NC(=O)C2=CC=C(C=C2)C3=NC4=C(N3C)C=CC(=C4)C(=O)NC5=CC=CC(=C5)CCOC(C)(C)C
Molecular Formula
C40H46N4O4
Molecular Weight
646.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
040676-HRP 200 µL
PTRH1, ID (PTRH1, C9orf115, Probable peptidyl-tRNA hydrolase) (Azide free) (HRP) discontinued
Sign In for Pricing
View Details 
132427-AP 100 µL
RCBTB2 (RCC1 and BTB Domain-containing Protein 2, Chromosome Condensation 1-like, CHC1-L, RCC1-like G Exchanging Factor, Regulator of Chromosome Condensation and BTB Domain-containing Protein 2, CHC1L, RLG) (AP) discontinued
Sign In for Pricing
View Details