RI-962
Product Specifications
CAS Number
2763831-53-2
Target
RIP kinase
Related Pathways
Apoptosis|||NF-?B
Purity
0.9939
Bioactivity
RI-962 is a potent and selective inhibitor of RIPK1 that dose-dependently protects cells from necrotic apoptosis induced by TNF?, Smac mimics, and Z-VAD-FMK by inhibiting RIPK1, RIPK3, and MLKL phosphorylation with EC50=10.0 nM~17.8 nM, and improves survival in mice in two models of inflammation.
Smiles
O=C(NC(C=1C=CC=CC1)C)C2=CN(C=3C=CC(=CC23)C=4C=CN5N=C(N=C5C4)NC(=O)C(C)C)C
Molecular Formula
C28H28N6O2
Molecular Weight
480.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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