LWG-301
Product Specifications
Target
Others, Apoptosis, Glutaminase
Related Pathways
Proteases/Proteasome, Others, Apoptosis
Bioactivity
LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.
Smiles
CCCCC(=O)NC1=NN=C(S1)NC2CCN(CC2)C3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OCCCC
Molecular Formula
C28H38N8O3S
Molecular Weight
566.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS714908-01 0.1 mL
Rabbit anti-human adaptor-related protein complex 3, beta 1 subunit polyclonal Antibody
Sign In for Pricing
View Details MBS714908-02 5x 0.1 mL
Rabbit anti-human adaptor-related protein complex 3, beta 1 subunit polyclonal Antibody
Sign In for Pricing
View Details MBS2053804-01 0.1 mL
APC/CY7-Linked Polyclonal Antibody to Glutathione Reductase (GR)
Sign In for Pricing
View Details MBS2053804-02 0.2 mL
APC/CY7-Linked Polyclonal Antibody to Glutathione Reductase (GR)
Sign In for Pricing
View Details MBS2053804-03 0.5 mL
APC/CY7-Linked Polyclonal Antibody to Glutathione Reductase (GR)
Sign In for Pricing
View Details