LWG-301
Product Specifications
Target
Others|||Apoptosis|||Glutaminase
Related Pathways
Proteases/Proteasome|||Others|||Apoptosis
Bioactivity
LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.
Smiles
CCCCC(=O)NC1=NN=C(S1)NC2CCN(CC2)C3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OCCCC
Molecular Formula
C28H38N8O3S
Molecular Weight
566.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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